IEDB Analysis Resource

MHC II Automated Server Benchmarks


This is a live ranking of MHC II servers based on performance, which continues to be reevaluated over time. The weekly IEDB releases are automatically checked for datasets large enough to add to the benchmarks. The benchmark metrics in the table below will only be updated on releases where such new data is becoming available.

Accumulated overall ranking scores

Ranking scores based on data sets submitted to the IEDB for the last at least 5 references.

Server 2019-03-22 2018-11-23 2017-12-29 2017-11-24 2017-08-18 2017-06-30 2017-04-28 2017-04-11 2016-12-31
NetMHCIIpan-3.1 83 79 76 72 68 66 83 - -
Consensus IEDB method 65 65 63 64 63 63 50 50 51
NN-align 57 64 66 65 68 63 72 72 65
SMM-align 55 42 38 45 46 36 43 46 46
Tepitope (Sturniolo) 18 41 45 45 43 60 15 17 25
Comblib matrices 10 4 0 0 0 0 13 6 15


Weekly ranking scores

Ranking scores based on data sets submitted to the IEDB within a single week.

Server 2019-03-22 2018-11-23 2017-12-29 2017-11-24 2017-08-18 2017-06-30 2017-04-28 2017-04-11 2016-12-31
NetMHCIIpan-3.1 83 90 67 100 75 75 25 56 -
Consensus IEDB method 57 90 83 50 75 60 100 56 51
NN-align 53 60 67 40 75 69 50 50 65
SMM-align 53 40 0 90 100 26 75 50 46
Tepitope (Sturniolo) 15 10 - 60 0 52 - 100 25
Comblib matrices - 20 - 0 - 0 - 0 15


Download initial benchmark datasets

Click here to download the initial benchmark datasets.